Non-waste energy and resource-saving heterogeneous catalytic methods of obtaining and transformation of cyclic acetalies and gem-dichlorocyclopropanes

. New methods and ways of using heterogeneous zeolite catalysts – H-Y, H-Beta, H-MOR, H-ZSM-5 and micro-meso-porous – H-Ymmm and others in organic synthesis were studied. Using the example of available petrochemical compounds such as polyols, olefins, and dienes, the possibilities of carrying out cyclization and condensation reactions in the presence of zeolites of various structural types are shown. It has been established that the H-Beta zeolite catalyst provides a quantitative yield of ethers and esters during the interaction of olefins – substituted vinyl-gem-dichlorocyclopropanes – with linear alcohols and acids, respectively. It has been determined that the condensation of styrene and an equimolar mixture of 4-hydroxymethyl-1,3-dioxolane and 5-hydroxy-1,3-dioxane in the presence of the H-Beta catalyst proceeds with the formation of ethers, while the ratio of 5 and 6-membered isomeric products = 1.2:1. Multicomponent condensations successfully proceed in one stage in the presence of wide-pore zeolites.


Introduction
The cyclic acetals and their derivatives are widely use in organic synthesis and find application as a component of solvents, plasticizers, anti-oxidants, inhibitors of the corrosion, bio-effecting agents and etc. [1][2][3]. Acid-catalyzed condensation of the carbonyl compounds with polyols and cyclization of olefins with formaldehyde (the Prince reaction) are basic manufacturing and preparative directions of creating the cycloacetal structure.
In the literature, there is no generalization and systematization of the results of studying wastefree energy-and resource-saving methods for the synthesis and transformation of cyclic acetals and gem-dichlorocyclopropanes. It was of interest to analyze the available data in terms of their prospects in the preparative synthesis of polyfunctional carbo-and heterocyclic compounds.
This review focuses for the first time on the efficiency of using heterogeneous catalysis methods for the preparation and conversion of cyclic acetals and gem-dichlorocyclopropanes.
Traditional homogeneous catalysts -mineral (phosphoric, sulfuric), organic (vinegar, oxalic) acids, the Lewis acids (ZnCl 2 , BF 3 , SnCl4) and other insure high yield and selectivity of targeted heterocycles formation. But their using connects with high consumption of the toxic organic solvents, high energy-wastes with divining and purification of targeted products, control of selectivity process' difficulty.
We studied the capability of replaced the homogeneous catalysts by zeolites of different modification in this process. This type of perspective heterogeneous catalysts has proven themselves in the isomerization, alkylation, condensation reactions etc. because allows selecting and using the zeolites with required characteristics (size of pores, geometry of channels and acidity) [4][5][6].

Materials and methods
The qualitative and quantitative compositions of the reaction masses were determined using mass spectrometry (using a Chromatek-Kristall 5000M device with the 2012 National Institute of Standards and Technology, USA database) and nuclear magnetic resonance spectroscopy (using a Bruker AM-500 device with operating frequencies of 500 and 125 MHz).

Results and discussion
In literature [7,8] was defined influence of carbonyl compounds structure (formaldehyde, aldehydes, acetone) on total yield of cyclic acetales and ratio of 5 and 6-unit heterocycles' formation.
It was fond that periodic or continuous condensation of different polyols (ethylene glycol, 1,2 and 1,3-propyleneglycol, glycerin etc.) with carbonyl compounds on acidic zeolites and molecular sieves, which able to absorb aqua, at 120-180°С in 1-4 hours, leads to appropriate 1,3-dioxacycloalkanes with virtually quantitate yield (Fig. 1). While the solvent not required, co-products absent, the stage of neutralization disappear, the catalyst can be use many times without regeneration. In the presence of the acidic zeolites sterol and -metylsterol react with the formaldehyde with quantitative formation of the appropriate 4-fenyl-1,3-dioxanes (Fig. 2). The process is ending in 1-2 hours at temperature 80-130 °С.  Wide series of gem-dichlorocyclopropanes is approach able based on manufacturing olefins and dienes. This specify the importance of their using in the organic synthesis. So the thermal (400-500°С) isomerization of vinyl-gem-dichlorocyclopropanes is allow obtaining the practically important gem-dichlorocyclopentenes [9], but their yields are less than 25-30 %. We offer the convenientselective obtaining method of the latest (Fig. 4) with heterogeneous-catalytic isomerization of vinyl-gem-dichlorocyclopropanes in presence of the zeolite SAPO-34 [10]. It was known way from available, based on derivatives of sterol, vinyl-gemdichlorocyclopropane to derivatives of phenylacroleinin conditions of homogeneous catalysis [11]. It needs to 18-24 h and 5-7-multipleexcess of alcohol for the obtaining of acceptable yields of 60-70 %.
We found [12] that heterogeneous catalyst -anionite АВ-17 allows carry out the reaction of with stoichiometric ratio of the reagents in 4-6 hours at 120-125°С temperature with yield 80-90 % of linear acetals (Fig. 5). The stage of alkaline flow utility and demand of purification and recycling of the solvents are excluded. Activity of the 2,3-diphenyl-1,1-dichlorocyclopropane isomers in the decomposition reaction is similar, and they are more active than 2-phenyl-1,1-dichlorocyclopropane. Probably, this is connected with presence of two isomers, which capable of 1,2-migration of benzyl hydrogen's atoms in 2 and 3 positions.
The structure of synthesized compounds was assigned based by data of NMR 1 H, 13 C and chromatography-mass spectrometry. The determined signals for the individual cis-, trans-compounds are the protons of the ОCHО group as a kind of singlet with chemical shift 5.77 and 4.94 ppm. respectively. Protons of the ester group CH 2 O in specter of the trans-acetale resonate at 3.67 ppm., and in cis-isomer -at 3.69 ppm. In 13 С NMR specter of trans-acetale the signals of carbonic atoms С = Сappears in more deficient space (114.97-141.16 ppm.) than the signals of similar atoms its cis-isomer (114.45 and 141.12 ppm.). The chemical shifts of carbon in ОСО group have a difference and there are 111.31 and 110.29 ppm. as respectively.

Fig. 6. Alkylation of benzene and its analogues with substituted vinyl-gem-dichlorocyclopropanes
It should be noted that under the studied conditions, the alkylation of toluene with 2-methyl-2-vinyl-gem-dichlorocyclopropane led to the formation of only the -isomers.
Favorite preparation of ethers and esters by addition of alcohols or mono-and dicarboxylic acids, respectively, to cycloolefin hydrocarbons was carried out in the presence of mineral or organic catalysts [14][15][16][17][18][19][20]. Reactions proceed at high temperatures and with low selectivity without a catalyst [21].
We have described [22,23] effective methods of ethers and esters preparation in 40-55 % yields by adding butanol or butyric acid to 2-vinyl-and 2-methyl-2-vinyl-gemdichlorocyclopropanes in the presence of a commercially available zeolite catalyst H-Beta (Fig. 7). Because esters containing functional groups are interest such intermediates of organic synthesis, we involved in the reaction [22] commercially available styrene and glycerol formals as an equimolar mixture of 4-hydroxymethyl-1,3-dioxolane and 5-hydroxy-1,3-dioxane and styrene. The formation 5-and 6-membered isomers = 1.2: 1 with a yield of 60 % was observed at a temperature 150 °С for 5 hours in the presence of H-Beta catalyst (Fig. 8).
Thus, the transfer of homogeneous catalytic cyclization and condensation reactions to heterogeneous catalysis conditions increases the yield and selectivity of target compounds, simplifies the isolation of aim products, and, as a rule, does not require of expensive toxic solvents using.

Conclusions
Studied new methods and ways of using heterogeneous zeolite catalysts in organic synthesis. Variants of cyclization and condensation are possible in the presence of structural type zeolites. It was found that zeolite catalysts have a number of complex output ethers and esters in the interaction of olefins with alcohols and acids of various structures.